Influence of glutamatergic and GABAergic neurotransmission on obstructive sleep apnea

نویسندگان

چکیده

Glutamate and γ-aminobutyric acid (GABA) are the two main neurotransmitters in human brain. The balance between their excitatory inhibitory functions is crucial for maintaining brain’s physiological functions. Disturbance of glutamatergic or GABAergic neurotransmission leads to serious health problems including neurodegeneration, affective sleep disorders. Both GABA glutamate involved control sleep–wake cycle. disturbances function may cause sleep-related Obstructive apnea (OSA) most common respiratory disorder characterized by repetitive collapse upper airway resulting intermittent hypoxia fragmentation. complex pathophysiology OSA basis development numerous comorbid diseases. There emerging evidence that be pathogenesis OSA, as well its comorbidities. Additionally, GABA/glutamate targeted pharmacotherapy also influence course which important implementation wildly used drugs benzodiazepines, anesthetics, gabapentinoids. In this review, we summarize current knowledge on obstructive apnea.

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ژورنال

عنوان ژورنال: Frontiers in Neuroscience

سال: 2023

ISSN: ['1662-453X', '1662-4548']

DOI: https://doi.org/10.3389/fnins.2023.1213971